Etymology: < Anglo-Norman pisser, Anglo-Norman and Old French pissier, 'urinate'. Probably of imitative origin. (OED, 2011)
1. trans. To annoy or irritate.
2011 PROFESSOR GREEN on Twitter, 14 Sep I'm just off to piss off some midgets so as I can call them short tempered. Back soon.
2. intr. Angry, fed up or frustrated. Freq. as pissed or pissed off.
2011 CHEA PUI YEE on Twitter, 14 Sep Pissed off sia trying so hard to sleep then everytime i fall into sleep some helper just come and talk to us.